Absorption and Drug Development: Solubility, Permeability, and Charge State: Fire Up Your People, Thrill Your Customers, and Crush Your Competitors Alex Avdeef

ISBN: 9781118057452

Published: May 22nd 2012

Hardcover

744 pages


Description

Absorption and Drug Development: Solubility, Permeability, and Charge State: Fire Up Your People, Thrill Your Customers, and Crush Your Competitors  by  Alex Avdeef

Absorption and Drug Development: Solubility, Permeability, and Charge State: Fire Up Your People, Thrill Your Customers, and Crush Your Competitors by Alex Avdeef
May 22nd 2012 | Hardcover | PDF, EPUB, FB2, DjVu, talking book, mp3, ZIP | 744 pages | ISBN: 9781118057452 | 4.49 Mb

Explains how to perform and analyze the results of the latest physicochemical methodsWith this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compoundsMoreExplains how to perform and analyze the results of the latest physicochemical methodsWith this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compounds pharmaceutical properties and their effects on drug absorption.

The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates.This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the authors research groupTwo new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrierExpanded information and methods to support pKa determinationNew examples explaining the treatment of practically insoluble test compoundsAdditional case studies demonstrating the use of the latest physicochemical techniquesNew, revised, and expanded database tables throughout the bookWell over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures.

In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book.This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.



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